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Vascular assessment of liver disease—towards a new frontier in MRI

机译:肝脏疾病的血管评估-迈向MRI的新领域

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摘要

Complex haemodynamic phenomena underpin the pathophysiology of chronic liver disease. Non-invasive MRI-based assessment of hepatic vascular parameters therefore has the potential to yield meaningful biomarkers for chronic liver disease. In this review, we provide an overview of vascular sequelae of chronic liver disease amenable to imaging evaluation and describe the current supportive evidence, strengths and the limitations of MRI methodologies, including dynamic contrast-enhanced, dynamic hepatocyte-specific contrast-enhanced, phase-contrast, arterial spin labelling and MR elastography in the assessment of hepatic vascular parameters. We review the broader challenges of quantitative hepatic vascular MRI, including the difficulties of motion artefact, complex post-processing, long acquisition times, validation and limitations of pharmacokinetic models, alongside the potential solutions that will shape the future of MRI and deliver this new frontier to the patient bedside.
机译:复杂的血液动力学现象是慢性肝病的病理生理基础。因此,基于MRI的非侵入性肝血管参数评估可能会产生有意义的慢性肝病生物标志物。在这篇综述中,我们概述了适合影像学检查的慢性肝病血管后遗症,并描述了目前的支持性证据,优势和MRI方法的局限性,包括动态对比增强,动态肝细胞特异性对比增强,阶段性对比,动脉自旋标记和MR弹性成像在评估肝血管参数中的作用。我们回顾了定量肝血管MRI的广泛挑战,包括运动伪影的困难,复杂的后处理,较长的采集时间,药代动力学模型的验证和局限性,以及可能影响MRI未来并提供这一新领域的潜在解决方案到病人床边。

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