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Antifungal agents and therapy for infants and children with invasive fungal infections: a pharmacological perspective

机译:婴幼儿侵袭性真菌感染的抗真菌药和治疗:药理学观点

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摘要

Invasive fungal infections, although relatively rare, are life-threatening diseases in premature infants and immunocompromised children. While many advances have been made in antifungal therapeutics in the last two decades, knowledge of the pharmacokinetics and pharmacodynamics of antifungal agents for infants and children remains incomplete. This review summarizes the pharmacology and clinical utility of currently available antifungal agents and discusses the opportunities and challenges for future research.
机译:侵袭性真菌感染虽然相对罕见,但在早产儿和免疫功能低下的儿童中是威胁生命的疾病。尽管在过去的二十年中抗真菌疗法取得了许多进展,但是对于婴幼儿抗真菌剂的药代动力学和药效学的知识仍然不完整。这篇综述总结了目前可用的抗真菌剂的药理学和临床用途,并讨论了未来研究的机遇和挑战。

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