A new formulation of tolevamer a novel nonantibiotic polymer is safe and well-tolerated in healthy volunteers: a randomized phase I trial

机译：一种新的非抗生素聚合物tolevamer的新配方在健康志愿者中安全且耐受性良好：一项随机I期试验

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摘要

AIMSTo evaluate the safety and tolerability of a new oral solution formulation of tolevamer potassium sodium, a nonantibiotic polymer that binds Clostridium difficile toxins A and B.

机译：目的评估一种新的口服托拉孕酮钾钠口服溶液制剂的安全性和耐受性，它是一种结合艰难梭菌毒素A和B的非抗生素聚合物。

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期刊名称 British Journal of Clinical Pharmacology
作者
Jennifer Peppe; Andrew Porzio; David M Davidson;
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作者单位

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年(卷),期 2008(66),1
年度 2008
页码 102–109
总页数 8
原文格式 PDF
正文语种
中图分类药学;
关键词
Clostridium difficile hypokalaemia nosocomial diarrhoea safety and efficacy tolevamer;

机译：艰难梭菌;低血钾症;医院腹泻;安全性和有效性;托拉莫;

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专利

1. A new formulation of tolevamer, a novel nonantibiotic polymer, is safe and well-tolerated in healthy volunteers: a randomized phase I trial. [J] . Peppe J, Porzio A, Davidson DM British Journal of Clinical Pharmacology . 2008,第1期

机译：一种新型的非抗生素聚合物tolevamer的新配方在健康志愿者中是安全且耐受性良好的：一项随机I期试验。
2. A new solid oral tablet formulation of posaconazole: a randomized clinical trial to investigate rising single- and multiple-dose pharmacokinetics and safety in healthy volunteers [J] . G. Krishna1* L. Ma1 M. Martinho1 R. A. Preston23 and E. OMara1† Journal of Antimicrobial Chemotherapy . 2012,第11期

机译：泊沙康唑的新型固体口服片剂：一项在健康志愿者中研究单剂量和多剂量药代动力学及安全性上升的随机临床试验
3. A new solid oral tablet formulation of posaconazole: A randomized clinical trial to investigate rising single- and multiple-dose pharmacokinetics and safety in healthy volunteers [J] . KrishnaG., MaL., MartinhoM., The Journal of Antimicrobial Chemotherapy . 2012,第11期

机译：泊沙康唑的新型固体口服片剂：一项在健康志愿者中研究单剂量和多剂量药代动力学及安全性上升的随机临床试验
4. A Phase I, Double-Blind, Randomized, Dose Escalating Crossover Study ofan Oral Formulation of Human Growth Hormone in Healthy Male Volunteers [C] . Steven M. Dinh, Puchun Liu, Ehud Arbit, Controlled Release Society annual meeting . 2004

机译：健康男性志愿者中人类生长激素口服制剂的I期，双盲，随机，剂量递增交叉研究
5. Hypotensive resuscitation versus standard fluid resuscitation for the management of trauma patients in hemorrhagic shock: The safety phase of a randomized controlled trial. [D] . Morrison, C. Anne. 2009

机译：低血压复苏与标准液体复苏在失血性休克中对创伤患者的处理：一项随机对照试验的安全性阶段。
6. A new solid oral tablet formulation of posaconazole: a randomized clinical trial to investigate rising single- and multiple-dose pharmacokinetics and safety in healthy volunteers [O] . G. Krishna, L. Ma, M. Martinho, -1

机译：泊沙康唑的新型固体口服片剂：一项在健康志愿者中研究单剂量和多剂量药代动力学及安全性上升的随机临床试验
7. A new formulation of tolevamer, a novel nonantibiotic polymer, is safe and well-tolerated in healthy volunteers: a randomized phase I trial [O] . Peppe, Jennifer, Porzio, Andrew, Davidson, David M 2008

机译：一种新的非抗生素聚合物tolevamer的新配方在健康志愿者中安全且耐受性良好：一项随机I期试验
8. Randomized Double-Blind Phase III Pivotal Field Trial of the Comparative Immunogenicity Safety and Tolerability of Two Yellow Fever 17D Vaccines (ARILVAX(Trademark) and YF-VAX(Trademark)) in Healthy Infants and Children in Peru [R] . Belmusto-Worn, V. E. , Sanchez, J. L. , McCarthy, K. , 2004

机译：秘鲁健康婴儿和儿童两种黄热病17D疫苗（aRILVaX（商标）和YF-VaX（商标））的比较免疫原性安全性和耐受性的随机双盲III期关键现场试验

A new formulation of tolevamer a novel nonantibiotic polymer is safe and well-tolerated in healthy volunteers: a randomized phase I trial

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