Enriched enrolment: definition and effects of enrichment and dose in trials of pregabalin and gabapentin in neuropathic pain. A systematic review

摘要

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT class="unordered" style="list-style-type:disc">Enriched enrolment (the exclusion of non-responders or specific inclusion of responders) is believed to add both to trial sensitivity and to the measured effect of an intervention.Enriched enrolment lacks specific definition, and the extent of any differences between results with non-enriched recruitment and enriched enrolment is not known.Enriched enrolment is thought to have influenced neuropathic pain trials.