Effect of timing of dosing in relation to food intake on the pharmacokinetics of esomeprazole

摘要

>What is already known about this subjectSystemic esomeprazole exposure is decreased when administered simultaneously with food.>What this study addsTaking esomeprazole within 15 min of eating a high-fat, high-calorie meal results in reduced systemic drug exposure.AimTo investigate the pharmacokinetics of esomeprazole before a high-fat meal vs. fasting.