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Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 1′-hydroxylation

机译：咪达唑仑1-羟基化作用测定含炔雌醇和孕二烯酮的口服避孕药对CYP3A4活性的影响

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摘要

AimsTo characterize the effect of an oral contraceptive (OC) containing ethinylestradiol and gestodene on the activity of CYP3A4 in vivo as measured by the 1′-hydroxylation of midazolam.

机译：目的通过口服咪达唑仑的1'-羟基化作用表征含有炔雌醇和孕二烯的口服避孕药（OC）对体内CYP3A4活性的影响。

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期刊名称 British Journal of Clinical Pharmacology
作者
Sanna Palovaara; Kari T Kivistö; Pasi Tapanainen; Pekka Manninen; Pertti J Neuvonen; Kari Laine;
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作者单位

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年(卷),期 2000(50),4
年度 2000
页码 333–337
总页数 5
原文格式 PDF
正文语种
中图分类药学;
关键词
CYP3A4 ethinylestradiol gestodene interaction midazolam;

机译：CYP3A4;乙炔雌二醇;孕二烯酮;相互作用;咪达唑仑;

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专利

1. Cycle Control, Safety and Acceptability of a New Oral Contraceptive Containing Ethinylestradiol 15 Micrograms and Gestodene 60 Micrograms [J] . Ladakan Jaithitivit, Unnop Jaisamrarn, Surasak Taneepanichskul Journal of the Medical Association of Thailand =: Chotmaihet thangphaet . 2012,第5期

机译：一种新的口服避孕药，含乙炔雌二醇15毫克和孕二烯酮60毫克，其循环控制，安全性和可接受性
2. Determination of Ethinylestradiol and Gestodene in Oral Contraceptives by Micellar Electrokinetic Chromatography [J] . J. J. Berzas, J. Rodriguez, G. Castaneda, Chromatographia . 1999,第1a2期

机译：胶束电动色谱法测定口服避孕药中的乙炔雌二醇和雌二醇
3. CYP3A4 intron 6 C>T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin [J] . ElensL., NieuweboerA., ClarkeS.J., Pharmacogenomics . 2013,第2期

机译：CYP3A4内含子6 C> T SNP（CYP3A4 * 22）编码癌症患者中较低的CYP3A4活性，用咪达唑仑和红霉素探针测量
4. In vivo cytochrome P450 3A activity in a pregnant woman as measured by endogenous cortisol 6β-hydroxylation clearance [C] . Hiromi Shibasaki-Hirano, Kaori Hosoda, Akitomo Yokokawa, International Mass Spectrometry Conference . 2014

机译：通过内源性皮质醇6β-羟基化清除测量的孕妇中体内细胞色素P450 3A活性
5. Defining the use of midazolam as a probe of CYP3A4 activity: Sensitive quantitation of the metabolites and characterization of mechanism-based inactivation [D] . Podoll, Terry Dean 1996

机译：定义将咪达唑仑用作CYP3A4活性的探针：代谢物的敏感定量和基于机理的失活的表征
6. An open-label two-period comparative study on pharmacokinetics and safety of a combined ethinylestradiol/gestodene transdermal contraceptive patch [O] . Chao Zhang, Haiyan Li, Xin Xiong, 2017

机译：乙炔雌二醇/孕二烯酮经皮避孕贴剂的药代动力学和安全性的开放标签两期比较研究
7. Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 1′-hydroxylation [O] . Palovaara, Sanna, Kivistö, Kari T, Tapanainen, Pasi, 2001

机译：咪达唑仑1'-羟基化作用测定含炔雌醇和孕二烯酮的口服避孕药对CYP3A4活性的影响

Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 1′-hydroxylation

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