Role of lapatinib alone or in combination in the treatment of HER2-positive breast cancer

机译：拉帕替尼单独或联合使用在治疗HER2阳性乳腺癌中的作用

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PurposeThis review aims to present the preclinical and clinical data regarding efficacy and safety of lapatinib alone and in combination with other agents in the treatment of human epidermal growth factor receptor-2 (HER2)-overexpressing breast cancer.

机译：目的这篇综述旨在提供有关拉帕替尼单独和与其他药物联合治疗人表皮生长因子受体2（HER2）过表达的乳腺癌的疗效和安全性的临床前和临床数据。

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期刊名称 Breast Cancer : Targets and Therapy
作者
Sara A Hurvitz; Reva Kakkar;
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作者单位

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年(卷),期 2012(4),-1
年度 2012
页码 35–51
总页数 17
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
human epidermal growth factor receptor 2 breast neoplasms central nervous system metastases trastuzumab;

机译：人表皮生长因子受体2;乳腺肿瘤;中枢神经系统转移;曲妥珠单抗;

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专利

1. Role of lapatinib alone or in combination in the treatment of HER2-positive breast cancer [J] . Sara A Hurvitz, Reva Kakkar Breast Cancer: Targets and Therapy . 2012,第1期

机译：拉帕替尼单独或联合使用在治疗HER2阳性乳腺癌中的作用
2. Phase Ib/II single-arm trial evaluating the combination of everolimus, lapatinib and capecitabine for the treatment of HER2-positive breast cancer with brain metastases (TRIO-US B-09) [J] . Sara Hurvitz, Rashi Singh, Brad Adams, Therapeutic advances in medical oncology. . 2018,第12期

机译：IB / II单臂试验评估everolimus，Lapatinib和Capecitabine的组合，用于治疗脑转移的Her2阳性乳腺癌（Trio-US B-09）
3. Phase II trial of a novel capecitabine dosing schedule in combination with lapatinib for the treatment of patients with HER2-positive metastatic breast cancer. [J] . Gajria D, Gonzalez J, Feigin K, Breast cancer research and treatment. . 2012,第1期

机译：新型卡培他滨给药方案与拉帕替尼联合治疗HER2阳性转移性乳腺癌患者的II期试验。
4. Elevated WBP2 Expression in HER2-Positive Breast Cancers Correlates with Sensitivity to Trastuzumab-Based Neo-Adjuvant Therapy: A Retrospective and Multicentric Study [C] . Yoon Pin Lim International Molecular Medicine Tri-Conference. . 2019

机译：HER2阳性乳腺癌中的WBP2表达升高与基于曲妥珠单抗的新辅助治疗的敏感性相关：回顾性和多中心研究
5. Role of Lapatinib and Retinoids In Overcoming Intrinsic Resistance to Hormonal Therapy In Breast Cancer [D] . Gilani, Rabia Afzal 2011

机译：拉帕替尼和类维生素A在克服乳腺癌激素治疗的内在抗性中的作用
6. The use of breast imaging for predicting response to neoadjuvant lapatinib trastuzumab and their combination in HER2-positive breast cancer: Results from Neo-ALTTO [O] . S. Di Cosimo, C. Campbell, H.A. Azim Jr, -1

机译：乳房成像在预测新辅助拉帕替尼曲妥珠单抗及其组合在HER2阳性乳腺癌中的反应：Neo-ALTTO的结果
7. Phase Ib/II single-arm trial evaluating the combination of everolimus, lapatinib and capecitabine for the treatment of HER2-positive breast cancer with brain metastases (TRIO-US B-09) [O] . Sara Hurvitz, Rashi Singh, Brad Adams, 2018

机译：IB / II单臂试验评估everolimus，Lapatinib和Capecitabine的组合，用于治疗脑转移的Her2阳性乳腺癌（Trio-US B-09）

Role of lapatinib alone or in combination in the treatment of HER2-positive breast cancer

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