Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization

摘要

BackgroundNicotinamide N-methyltransferase (NNMT) is overexpressed in various human tumors and involved in the development and progression of several carcinomas. In breast cancer, NNMT was found to be overexpressed in several cell lines. However, the clinical relevance of NNMT in breast cancer is not yet clear.