Inverse baseline expression pattern of the NEPeuropeptides and NFκB/proteasome pathways in androgen-dependent and androgen-independent prostate cancer cells

摘要

BackgroundCastration-resistance in prostate cancer (PC) is a critical event hallmarking a switch to a more aggressive phenotype. Neuroendocrine differentiation and upregulation of NFκB transcriptional activity are two mechanisms that have been independently linked to this process.