Mean platelet volume is associated with myocardial perfusion defect in diabetic patients

摘要

Diabetes mellitus (DM) is considered a coronary artery risk equivalent. DM is associated with an increased risk of cardiovascular morbidity and mortality., DM may cause myocardial perfusion defects involving the main coronary artery and myocardial microvascular circulation. Myocardial perfusion imaging (MPI) is a useful non-invasive tool to determine whether there is a myocardial perfusion defect.Platelet volume is a marker of platelet activation and function and is measured as mean platelet volume (MPV). MPV has become a prognostic factor in coronary heart disease and may eventually be accepted as a parameter of platelet activity. MPV is emerging as a new risk factor for vascular complications of DM of which atherothrombosis plays a crucial role.However, to the best of our knowledge, there have been no reports in the literature to evaluate the relationship between MPV and myocardial perfusion defect using MPI in patients with diabetes. Our aim was to evaluate whether there was a relationship between myocardial perfusion defect using myocardial perfusion scintigraphy and MPV in selected diabetic patients.