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Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature

机译:质子泵抑制剂对血小板计数的不良影响:一例报道并文献复习

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摘要

Proton pump inhibitors (PPIs) are the most effective and preferred class of drugs used to treat peptic ulcer disease, gastroesophageal reflux disease, and other diseases associated with increased production of gastric acid. PPIs in general have an excellent long-term safety profile and are well-tolerated. However, studies have shown some adverse reactions (e.g., osteoporosis, Clostridium difficile-associated diarrhea, Vitamin B12 and iron deficiency, and acute interstitial nephritis) on long-term PPI use. Thrombocytopenia attributed to use of PPIs has been described in a few case reports and a retrospective study. In this case report, we describe a case of PPI-induced thrombocytopenia. In our patient, thrombocytopenia immediately developed after the initiation of PPI on two separate occasions and resolved after its discontinuation. The strong association found in our case implies the potential role of PPI in causing this rare but serious adverse reaction. Based on this case report and the observation from other studies, a PPI-induced adverse event should be considered as a possible etiology for new-onset idiopathic thrombocytopenia.
机译:质子泵抑制剂(PPI)是用于治疗消化性溃疡疾病,胃食管反流疾病以及其他与胃酸产生增加有关的疾病的最有效和首选的药物。通常,PPI具有出色的长期安全性,并且具有良好的耐受性。但是,研究表明,长期服用PPI会产生一些不良反应(例如,骨质疏松症,艰难梭菌相关性腹泻,维生素B12和铁缺乏症以及急性间质性肾炎)。少数病例报告和回顾性研究描述了归因于PPI的血小板减少症。在此病例报告中,我们描述了PPI诱导的血小板减少症。在我们的患者中,血小板减少症是在两次不同的情况下立即开始PPI后发生的,并在停药后消失。在我们的案例中发现的强关联性暗示了PPI在引起这种罕见但严重的不良反应中的潜在作用。根据该病例报告和其他研究的观察,应将PPI引起的不良事件视为新发特发性血小板减少症的可能病因。

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