YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts

机译：YAP / TAZ通过经由AP-1诱导人皮肤真皮成纤维细胞中的Smad7来调节TGF-β/ Smad3信号传导

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BackgroundTranscription factors YAP and TAZ function as the primary mediators of the Hippo pathway. Yet, crosstalk of YAP and TAZ with other signaling pathways remains relatively unexplored. We have explored the impact of YAP and TAZ levels on the TGF-β/Smad signaling pathway in human skin dermal fibroblasts.

机译：背景转录因子YAP和TAZ充当河马途径的主要介质。然而，YAP和TAZ与其他信号通路的串扰仍然相对未开发。我们已经探索了YAP和TAZ水平对人皮肤真皮成纤维细胞中TGF-β/ Smad信号通路的影响。

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期刊名称 Cell Communication and Signaling : CCS
作者
Zhaoping Qin; Wei Xia; Gary J. Fisher; John J. Voorhees; Taihao Quan;
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作者单位

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年(卷),期 2018(16),-1
年度 2018
页码 18
总页数 12
原文格式 PDF
正文语种
中图分类细胞生物学;
关键词
YAP TAZ TGF-β/Smad Smad7;

机译：YAP;TAZ;TGF-β/ Smad;Smad7;

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专利

1. YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts [J] . Zhaoping Qin, Wei Xia, Gary J. Fisher, Cell Communication and Signaling . 2018,第1期

机译：YAP / TAZ通过经由AP-1诱导人皮肤真皮成纤维细胞中的Smad7来调节TGF-β/ Smad3信号传导
2. Protective Effect of Sulfated Polysaccharides from Celluclast-Assisted Extract of Hizikia fusiforme Against Ultraviolet B-Induced Skin Damage by Regulating NF-κB, AP-1, and MAPKs Signaling Pathways In Vitro in Human Dermal Fibroblasts [J] . Lei Wang, WonWoo Lee, Jae Young Oh, Marine Drugs . 2018,第7期

机译：纤维状裂殖酵母提取物中硫酸多糖对人皮肤成纤维细胞中NF-κB，AP-1和MAPKs信号通路的调控，对紫外线B诱导的皮肤损伤的保护作用
3. Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts [J] . Bing Tang, Bin Zhu, Yueying Liang, Archives of Dermatological Research . 2011,第8期

机译：积雪草苷通过诱导瘢痕loid成纤维细胞中的Smad7并抑制TGF-βRI和TGF-βRII来抑制胶原蛋白表达和TGF-β/ Smad信号传导
4. A Novel TGF-βreceptor (r150) Expressed on Human Keratinocytes Regulate TGF-βSignaling and Responses [C] . A. Philip, B. Tam, J. Wang Annual meeting of the Society For Biomaterials . 2003

机译：在人类角质形成细胞上表达的新型TGF-β受体（r150）调节TGF-β信号转导和反应。
5. Antioxidant defense and redox responses to telomere homolog oligonucleotides in human dermal fibroblasts: A model for investigating redox signaling responses to DNA damage. [D] . Lee-Bellantoni, Margaret So He. 2005

机译：对人类皮肤成纤维细胞中端粒同源寡核苷酸的抗氧化防御和氧化还原反应：研究对DNA损伤的氧化还原信号反应的模型。
6. Protective Effect of Sulfated Polysaccharides from Celluclast-Assisted Extract of Hizikia fusiforme Against Ultraviolet B-Induced Skin Damage by Regulating NF-κB AP-1 and MAPKs Signaling Pathways In Vitro in Human Dermal Fibroblasts [O] . Lei Wang, WonWoo Lee, Jae Young Oh, 2018

机译：纤维状辅助裂殖酵母提取物中硫酸多糖对人皮肤成纤维细胞中NF-κBAP-1和MAPKs信号传导途径的调节对紫外线B诱导的皮肤损伤的保护作用
7. TGF-β/Smad3 Signaling Regulates Brown Adipocyte Induction in White Adipose Tissue [O] . Yadav, Hariom, Rane, Sushil G 2012

机译：TGF-β/ Smad3信号调节白色脂肪组织中的棕色脂肪细胞诱导。

YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts

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