WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer

机译：WDR76降解RAS并抑制大肠癌中的癌症干细胞活化

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BackgroundStabilization of RAS is a key event for the hyper-activation of Wnt/β-catenin signaling and activation of cancer stem cell (CSC) in colorectal cancer (CRC). WD Repeat protein 76 (WDR76) mediates the polyubiquitination-dependent degradation of RAS in hepatocellular carcinoma (HCC). We investigated whether WDR76 destabilizes RAS and acts as a tumor suppressor inhibiting CSC activation in CRC.

机译：背景技术RAS的稳定化是Wnt /β-catenin信号过度活化和结直肠癌（CRC）中癌症干细胞（CSC）活化的关键事件。 WD重复蛋白76（WDR76）介导肝细胞癌（HCC）中RAS的多聚泛素化依赖性降解。我们调查了WDR76是否使RAS不稳定并充当抑制CRC中CSC激活的肿瘤抑制因子。

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期刊名称 Cell Communication and Signaling : CCS
作者
Eun Ji Ro; Yong-Hee Cho; Woo-Jeong Jeong; Jong-Chan Park; Do Sik Min; Kang-Yell Choi;
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作者单位

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年(卷),期 2019(17),-1
年度 2019
页码 88
总页数 13
原文格式 PDF
正文语种
中图分类细胞生物学;
关键词
Colorectal Cancer RAS stability WDR76 Cancer stem cell Tumor suppressor;

机译：大肠癌;RAS稳定性;WDR76;癌干细胞;抑癌剂;

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专利

1. WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer [J] . Eun Ji Ro, Yong-Hee Cho, Woo-Jeong Jeong, Cell Communication and Signaling . 2019,第1期

机译：WDR76降解RAS并抑制大肠癌中的癌症干细胞活化
2. Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem-like Cells [J] . Hogstrom Jenny, Heino Sarika, Kallio Pauliina, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2018,第20期

机译：转录因子Prox1通过核细胞体重塑和脱乙酰酶复合物在结肠直肠癌干燥细胞中抑制Notch途径激活
3. The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3 beta-dependent threonine-286 phosphorylation in human colorectal cancer cells [J] . Park Gwang Hun, Song Hun Min, Jeong Jin Boo Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research . 2016,第Null期

机译：咖啡二萜甘醇在人大肠癌细胞中通过ERK1 / 2，JNK和GKS3β依赖性苏氨酸286磷酸化诱导细胞周期蛋白D1蛋白酶体降解来抑制细胞增殖
4. Graphitised carbon LC-MS identification of cancer specific glycosylation of uPAR and integrin beta6 from colorectal cancer cells [C] . Ruby P. Estrella, Alison Kan, David Cantor, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：石墨化碳LC-MS鉴定癌细胞癌细胞癌细胞和整合蛋白β6的鉴定型癌细胞
5. γ-Tocotrienol Suppresses Warburg Effect in Human Breast Cancer Cells Through Activation of Ampk and Modulation of Mitochondrial Dynamics [D] . Dronamraju, Venkateshwara Rao. 2019

机译：γ-生育三烯酚通过激活Ampk和调节线粒体动力学来抑制人乳腺癌细胞的Warburg效应
6. Metformin Suppresses Cancer Stem Cells through AMPK Activation and Inhibition of Protein Prenylation of the Mevalonate Pathway in Colorectal Cancer [O] . Yoojeong Seo, Janghyun Kim, Soo Jung Park, 2020

机译：二甲双胍通过AMPK活化和抑制成直肠癌中甲戊酯途径的蛋白质镇静的抑制癌干细胞
7. WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer [O] . Eun Ji Ro, Yong-Hee Cho, Woo-Jeong Jeong, 2019

机译：WDR76降解Ras并抑制结直肠癌中的癌症干细胞活化

WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer

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