Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation

机译：Flavokawain B靶向蛋白质的腺苷酸化通过Skp2降解增强硼替佐米的抗前列腺癌作用

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BackgroundFlavokawain B (FKB) has been identified from kava root extracts as a potent apoptosis inducer for inhibiting the growth of various cancer cell lines, including prostate cancer. However, the molecular targets of FKB in prostate cancer cells remain unknown.

机译：背景技术从卡瓦根提取物中已鉴定出黄酮类固醇B（FKB）是一种有效的凋亡诱导剂，可抑制包括前列腺癌在内的各种癌细胞系的生长。但是，FKB在前列腺癌细胞中的分子靶点仍然未知。

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期刊名称 Cell Communication and Signaling : CCS
作者
Xuesen Li; Victor Pham; Matthew Tippin; Dongjun Fu; Raymond Rendon; Liankun Song; Edward Uchio; Bang H. Hoang; Xiaolin Zi;
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作者单位

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年(卷),期 2019(17),-1
年度 2019
页码 25
总页数 13
原文格式 PDF
正文语种
中图分类细胞生物学;
关键词
Chalcone Neddylation Skp2 And prostate cancer;

机译：查尔酮;Neddylation;Skp2和前列腺癌;

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专利

1. Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation [J] . Xuesen Li, Victor Pham, Matthew Tippin, Cell Communication and Signaling . 2019,第1期

机译：Flavokawain B靶向蛋白质Neddylation，通过SKP2降解提高硼替佐米的抗前列腺癌效应
2. Gartanin is a novel NEDDylation inhibitor for induction of Skp2 degradation, FBXW2 expression, and autophagy [J] . Pham Victor, Rendon Raymond, Le Vinh X., Molecular Carcinogenesis . 2020,第2期

机译：Gartanin是一种用于诱导SKP2降解，FBXW2表达和自噬的新丁基化抑制剂
3. Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation [J] . Yuan-Hua Wu, Wun-Syuan Wu, Li-Ching Lin, Journal of experimental & clinical cancer research : . 2018,第1期

机译：硼替佐米通过诱导自噬介导的TRAF6癌蛋白降解增强口腔癌的放射敏感性
4. Paclitaxel-Loaded Micelles Modified with MCF-7 Cell-Specific Phage Protein: Enhance Selective Binding to Target Cancer Cells and Increased Cytotoxicity [C] . Tao Wang, Avni Clerk, Valery A Petrenko, Annual meeting exposition of the Controlled Release Society . 2010

机译：载有紫杉醇的胶束用MCF-7细胞特异性噬菌体蛋白修饰：增强对靶癌细胞的选择性结合并增加细胞毒性
5. Targeted Degradation of the MYC Oncogene Using PP2A-B56alpha Selective Small Molecule Modulators of Proteinphosphatase 2A as a Therapeutic Strategy for Treating Myc-Driven Cancers [D] . Farrington, Caroline C. 2020

机译：使用PP2A-B56α选择性小分子调节剂的蛋白质磷酸酶2a的靶向降解Myc癌基因作为治疗Myc驱动癌症的治疗策略
6. Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation [O] . Yuan-Hua Wu, Wun-Syuan Wu, Li-Ching Lin, 2018

机译：硼替佐米通过诱导自噬介导的TRAF6癌蛋白降解增强口腔癌的放射敏感性
7. Gartanin is a novel NEDDylation inhibitor for induction of Skp2 degradation, FBXW2 expression, and autophagy [O] . Victor Pham, Raymond Rendon, Vinh X. Le, 2019

机译：Gartanin是一种用于诱导SKP2降解，FBXW2表达和自噬的新型Neddylation抑制剂

Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation

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