Orai/CRACM1 and KCa3.1 ion channels interact in the human lung mast cell plasma membrane

摘要

BackgroundOrai/CRACM1 ion channels provide the major Ca²⁺ influx pathway for FcεRI-dependent human lung mast cell (HLMC) mediator release. The Ca²⁺-activated K⁺ channel KCa3.1 modulates Ca²⁺ influx and the secretory response through hyperpolarisation of the plasma membrane. We hypothesised that there is a close functional and spatiotemporal interaction between these Ca²⁺- and K⁺-selective channels.