Evaluation of The Combined Effects of HyperthermiaCobalt-60 Gamma Rays and IUdR on CulturedGlioblastoma Spheroid Cells and DosimetryUsing TLD-100

摘要

ObjectiveIn radiation treatment, the irradiation which is effective enough to control the tumors far exceeds normal-tissues tolerance. Thus to avoid such unfavourable outcomes, some methods sensitizing the tumor cells to radiation are used. Iododeoxyuridine (IUdR) is a halogenated thymidine analogue that known to be effective as a radiosensitizer in human cancer therapy. Improving the potential efficacy of radiation therapy after combining to hyperthermia depends on the magnitude of the differential sensitization of the hyperthermic effects or on the differential cytotoxicity of the radiation effects on the tumor cells. In this study, we evaluated the combined effects of IUdR, hyperthermia and gamma rays of ⁶⁰Co on human glioblastoma spheroids culture.