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Retinoic acid-induced 2 (RAI2) is a novel tumor suppressor and promoter region methylation of RAI2 is a poor prognostic marker in colorectal cancer

机译：维甲酸诱导的2（RAI2）是一种新型的肿瘤抑制因子RAI2的启动子区域甲基化在结直肠癌中是不良的预后标志物

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摘要

BackgroundReduced expression of retinoic acid-induced 2 (RAI2) was found in breast cancer. The regulation and function of RAI2 in human colorectal cancer (CRC) remain unclear.

机译：背景在乳腺癌中发现了维甲酸诱导2（RAI2）的表达降低。 RAI2在人类大肠癌（CRC）中的调控和功能仍不清楚。

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期刊名称 Clinical Epigenetics
作者
Wenji Yan; Kongming Wu; James G. Herman; Xiuduan Xu; Yunsheng Yang; Guanghai Dai; Mingzhou Guo;
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作者单位

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年(卷),期 2018(10),-1
年度 2018
页码 69
总页数 14
原文格式 PDF
正文语种
中图分类遗传学 ;
关键词
RAI2 DNA methylation Colorectal cancer AKT signaling 5-Aza-2′-deoxycytidine;

机译：RAI2;DNA甲基化;大肠癌;AKT信号传导;5-Aza-2-脱氧胞苷;

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专利

1. Identification and characterization of the human homologue (RAI2) of a mouse retinoic acid-induced gene in Xp22. [J] . Walpole SM, Hiriyana KT, Nicolaou A, Genomics . 1999 ,第3期

机译：小鼠视黄酸诱导的Xp22基因的人类同源物（RAI2）的鉴定和表征。
2. Promoter hypermethylation inactivate tumor suppressor FAM134B FAM134B and is associated with poor prognosis in colorectal cancer [J] . Islam Farhadul, Gopalan Vinod, Pillai Suja, Genes, Chromosomes and Cancer . 2018 ,第5期

机译：启动子高甲基化失活肿瘤抑制剂FAM134B FAM134B，与结直肠癌预后差有关
3. Regulation of MLH1 mRNA and protein expression by promoter methylation in primary colorectal cancer: A descriptive and prognostic cancer marker study [J] . JensenL.H., RasmussenA.A., ByrielL., Cellular oncology . 2013 ,第5期

机译：启动子甲基化对大肠癌MLH1 mRNA和蛋白表达的调控：描述性和预后性癌症标志物的研究
4. Tumor Budding as a Prognostic Marker in Stage III Colorectal Carcinoma [C] . H.J. Choi, K.J. Park, J.S. Shin, International Society of University Colon and Rectal Surgeons . 2006

机译：肿瘤芽为III阶段结直肠癌中的预后标志物
5. Detection of Methylation Targets in Advanced Adenoma in African Americans: Discovery of Colorectal Cancer Risk Markers. [D] . Rahi, Hamed. 2014

机译：非洲裔美国人晚期腺瘤中甲基化靶标的检测：结直肠癌危险标志物的发现。
6. The Relationship between the Methylation of Promoter Regions of Tumor Suppressor Genes PTEN and APC with Endometrial Cancer [O] . Tayebeh Ghazanfari, Golnaz Asaadi Tehrani, Parisa Maziri 2019

机译：抑癌基因PTEN和APC启动子区甲基化与子宫内膜癌的关系
7. Retinoic acid-induced 2 (RAI2) is a novel tumor suppressor, and promoter region methylation of RAI2 is a poor prognostic marker in colorectal cancer [O] . Wenji Yan, Kongming Wu, James G. Herman, 2018

机译：视黄酸诱导的2（RAI2）是一种新型肿瘤抑制剂，RAI2的启动子区甲基化是结直肠癌中的差的预后标志物

Retinoic acid-induced 2 (RAI2) is a novel tumor suppressor and promoter region methylation of RAI2 is a poor prognostic marker in colorectal cancer

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