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Effects of Melatonin Levels on Neurotoxicity of the Medial Prefrontal Cortex in a Rat Model of Parkinsons Disease

机译：褪黑激素水平对帕金森病大鼠模型内侧前额叶皮层神经毒性的影响

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摘要

Background:Damage of the medial prefrontal cortex (mPFC) results in similar characteristics to the cognitive deficiency seen with the progress of Parkinson's disease (PD). Since the course of mPFC damage is still unclear, our study aimed to investigate the effects of melatonin (MT) on neurotoxicity in the mPFC of a rat model of PD.

机译：背景：内侧前额叶皮层（mPFC）损伤的特征与帕金森氏病（PD）进展中所见的认知缺陷相似。由于mPFC损伤的过程尚不清楚，我们的研究旨在研究褪黑激素（MT）对PD大鼠的mPFC神经毒性的影响。

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期刊名称 Chinese Medical Journal
作者
Yan Li; Shu-Mei Wang; Lei Guo; Jian Zhu; Ying Wang; Lei Li; Yan-Xin Zhao;
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作者单位

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年(卷),期 2017(130),22
年度 2017
页码 2726–2731
总页数 6
原文格式 PDF
正文语种
中图分类基础医学;
关键词
Medial Prefrontal Cortex Melatonin Pinealectomy Tyrosine Hydroxylase Ventral Tegmental Area;

机译：内侧前额叶皮层;褪黑激素;松果体切除术;酪氨酸羟化酶;腹侧被盖区;

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专利

1. Effects of Melatonin Levels on Neurotoxicity of the Medial Prefrontal Cortex in a Rat Model of Parkinson's Disease [J] . Yan Li, Shu-Mei Wang, Lei Guo, 中华医学杂志（英文版） . 2017,第022期

机译：褪黑激素水平对帕金森病大鼠模型内侧前额叶皮层神经毒性的影响
2. In vivo effects of activation and blockade of 5-HT(2A/2C) receptors in the firing activity of pyramidal neurons of medial prefrontal cortex in a rodent model of Parkinson's disease. [J] . Wang S, Zhang QJ, Liu J Experimental Neurology . 2009,第1期

机译：5-HT（2A / 2C）受体的激活和阻断在帕金森氏病啮齿动物模型中前额叶皮层锥体神经元放电中的体内作用。
3. Limitations of the rat medial forebrain lesion model to study prefrontal cortex mediated cognitive tasks in Parkinson's disease [J] . Marshall Courtney A., King Kirsten M., Kortagere Sandhya Brain research . 2018,第期

机译：大鼠内侧前脑病变模型研究前额外皮质介导的认知任务在帕金森病中的认知任务的局限性
4. The Long Lasting Effect of Neonatal Handling on mGluR5 and Arc mRNA Levels in Medial Prefrontal Cortex of rat Brain [C] . Maria Nikolakopoulou, Anna Abatzi, Panagiotis Giompres, Brain Function Assessment in Learning . 2017

机译：新生儿处理对大鼠大脑内侧前额叶皮层mGluR5和Arc mRNA水平的长期影响
5. Sex Differences in the Effects of Two-Hit Stress on the Structure and Function of Rat Medial Prefrontal Cortex [D] . Moench, Kelly M. 2019

机译：两击应激对大鼠内侧前额叶皮层结构和功能影响的性别差异
6. Effects of cariprazine on extracellular levels of glutamate GABA dopamine noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity [O] . Jan Kehr, Takashi Yoshitake, Fumio Ichinose, -1

机译：氯吡嗪对大鼠精神分裂症苯环利定模型中前额叶内侧皮质谷氨酸GABA多巴胺去甲肾上腺素和5-羟色胺的细胞外水平的影响通过微透析和同步记录运动能力
7. Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity [O] . Jan Kehr, Takashi Yoshitake, Fumio Ichinose, 2018

机译：微透析研究细胞肠蛋白前列位于植物前甲胺类谷氨酸，GABA，多巴胺，去甲肾上腺素和血清素蛋白酶蛋白质前甲酸甲酯的影响及运动活性的同时记录
8. Medial Prefrontal Cortex and HPA Axis Roles in Generation of PTSD-Like Symptoms in SPS Model. [R] . I. Liberzon S. A. George 2012

机译：内侧前额叶皮层和Hpa轴角色在sps模型中产生类似pTsD的症状。

Effects of Melatonin Levels on Neurotoxicity of the Medial Prefrontal Cortex in a Rat Model of Parkinsons Disease

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