The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes

机译：食道器官系统揭示了反应性上皮变化中缺口和细胞因子之间的功能相互作用

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Background & AimsAberrations in the esophageal proliferation-differentiation gradient are histologic hallmarks in eosinophilic esophagitis (EoE) and gastroesophageal reflux disease. A reliable protocol to grow 3-dimensional (3D) esophageal organoids is needed to study esophageal epithelial homeostasis under physiological and pathologic conditions.

机译：背景与目的食管增殖分化梯度的异常是嗜酸性食管炎（EoE）和胃食管反流病的组织学标志。需要一种可靠的协议来生长3维（3D）食道类器官，以研究在生理和病理条件下的食道上皮稳态。

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期刊名称 Cellular and Molecular Gastroenterology and Hepatology
作者
Yuta Kasagi; Prasanna M. Chandramouleeswaran; Kelly A. Whelan; Koji Tanaka; Veronique Giroux; Medha Sharma; Joshua Wang; Alain J. Benitez; Maureen DeMarshall; John W. Tobias; Kathryn E. Hamilton; Gary W. Falk; Jonathan M. Spergel; Andres J. Klein-Szanto; Anil K. Rustgi; Amanda B. Muir; Hiroshi Nakagawa;
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年(卷),期 2018(5),3
年度 2018
页码 333–352
总页数 20
原文格式 PDF
正文语种
中图分类免疫学;
关键词
Three-Dimensional Keratinocytes Eosinophilic Esophagitis Squamous Cell Differentiation;

机译：三维角质形成细胞;嗜酸性食管炎;鳞状细胞分化;

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专利

1. Modeling Epithelial Homeostasis and Reactive Epithelial Changes in Human and Murine Three‐Dimensional Esophageal Organoids [J] . Nakagawa Hiroshi, Kasagi Yuta, Karakasheva Tatiana A., Current protocols in stem cell biology . 2020,第期

机译：造型上皮性稳态和人体和鼠三维食道子体的活性上皮变化
2. The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. [J] . Okawa T, Michaylira CZ, Kalabis J, Genes and Development: a Journal Devoted to the Molecular Analysis of Gene Expression in Eukaryotes, Prokaryotes, and Viruses . 2007,第21期

机译：食管上皮细胞中EGFR过度表达，hTERT激活和p53突变与基质成纤维细胞激活之间的功能相互作用诱导了肿瘤的发展，侵袭和分化。
3. Long-term organoid culture reveals enrichment of organoid-forming epithelial cells in the fimbrial portion of mouse fallopian tube - ScienceDirect [J] . Ying Xie, Eun-Sil Park, Dongxi Xiang, Stem cell research . 2018,第2期

机译：长期类器官培养可揭示小鼠输卵管纤维部分中类器官形成上皮细胞的富集-ScienceDirect
4. Self-assembled multifunctional nanogel reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells [C] . Rui Li, Kiara Bruggeman, David R Nisbet, World biomaterials congress . 2016

机译：自组装多功能纳米凝胶可降低促炎细胞因子的表达，从而诱导上皮癌细胞的凋亡
5. Regulation of muc1 expression by cytokine and progesterone receptor interplay in HES, a human uterine epithelial cell line, and expression of human MUC1 during early pregnancy in a human MUC1 transgenic mouse model. [D] . Dharmaraj, Neeraja. 2009

机译：在人类MUC1转基因小鼠模型中，通过人子宫上皮细胞系HES中细胞因子和孕激素受体相互作用对muc1表达的调节，以及人类MUC1的表达。
6. The functional interplay between EGFR overexpression hTERT activation and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development invasion and differentiation [O] . Takaomi Okawa, Carmen Z. Michaylira, Jiri Kalabis, 2007

机译：食管上皮细胞中EGFR过度表达hTERT激活和p53突变与基质成纤维细胞激活之间的功能相互作用诱导肿瘤的发生侵袭和分化
7. The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes [O] . Yuta Kasagi, Prasanna M. Chandramouleeswaran, Kelly A. Whelan, 2018

机译：食管有机体系揭示了活性上皮改变中凹口和细胞因子之间的功能相互作用

The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes

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