The effect of antilymphocytic antibody on the humoral immune response of different strains of mice. V. Effects on the class and subclass of antibody produced and the antibody responses of congenitally athymic mice

摘要

Antilymphocytic globulin (ALG) depressed the antibody responses of mice to SRBC as measured in terms of splenic PFCs of IgM, IgG1, IgG2a and IgG2b specificity. This effect was apparent over a range of antigen doses. ALG also reduced the antibody responses of congenitally athymic mice to SRBC and SIII. The possible mode of action of ALG is discussed in the light of these, and other, observations.