Antileishmanial activity and immunomodulatory effect ofsecosubamolide a butanolide isolated fromNectandra oppositifolia (Lauraceae)

摘要

Background:Visceral leishmaniasis is a complex neglected tropical disease caused by Leishmania donovani complex. Its current treatment reveals strong limitations, especially high toxicity. In this context, natural products are important sources of new drug alternatives for VL therapy. Therefore, the antileishmanial and immunomodulatory activity of compounds isolated from Nectandra oppositifolia (Lauraceae) was investigated herein.