Effects of glucose-dependent insulinotropic polypeptide on gastric emptying glycaemia and insulinaemia during critical illness: a prospective double blind randomised crossover study

摘要

IntroductionInsulin is used to treat hyperglycaemia in critically ill patients but can cause hypoglycaemia, which is associated with poorer outcomes. In health glucose-dependent insulinotropic polypeptide (GIP) is a potent glucose-lowering peptide that does not cause hypoglycaemia. The objectives of this study were to determine the effects of exogenous GIP infusion on blood glucose concentrations, glucose absorption, insulinaemia and gastric emptying in critically ill patients without known diabetes.