Mechanisms of leukocyte distribution during sepsis: an experimental study on the interdependence of cell activation shear stress and endothelial injury

摘要

IntroductionThis study was carried out to determine whether interactions of cell activation, shear stress and platelets at sites of endothelial injury explain the paradoxical maldistribution of activated leukocytes during sepsis away from local sites of infection towards disseminated leukocyte accumulation at remote sites.