Tight glycaemic control emerged on the scene of critical care in 2001. Surprisingly, not many confirmation trials have been published so far. The randomised controlled trial by De La Rosa and colleagues is a timely and valuable attempt to repeat the landmark Leuven studies. The failure to replicate the beneficial effects of tight glycaemic control may boil down to some less obvious defaults in the set-up of the trial despite a seemingly adequate study design. The incorporation of ample power calculations and strict adherence to glucose targets are essential to fairly compare studies on tight blood glucose control. Only if these basic conditions of study design are fulfilled can the effectiveness of the therapy be assessed.
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机译：严格的血糖控制在2001年出现在重症监护现场。令人惊讶的是，迄今为止，尚未发表很多确认试验。 De La Rosa及其同事进行的随机对照试验是一次及时且有价值的尝试，旨在重复具有里程碑意义的鲁汶研究。尽管看似足够的研究设计，但未能复制严格的血糖控制的有益效果可能归结为试验设置中一些不太明显的默认值。充足的功率计算和严格遵守血糖指标的结合对于公平比较严格的血糖控制研究至关重要。只有满足研究设计的这些基本条件，才能评估治疗的有效性。
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