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Organ donation after circulatory death: the forgotten donor?

机译:循环系统死亡后的器官捐献:被遗忘的捐献者?

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摘要

Donation after circulatory death (DCD) can be performed on neurologically intact donors who do not fulfill neurologic or brain death criteria before circulatory arrest. This commentary focuses on the most controversial donor-related issues anticipated from mandatory implementation of DCD for imminent or cardiac death in hospitals across the USA. We conducted a nonstructured review of selected publications and websites for data extraction and synthesis. The recommended 5 min of circulatory arrest does not universally fulfill the dead donor rule when applied to otherwise neurologically intact donors. Scientific evidence from extracorporeal perfusion in circulatory arrest suggests that the procurement process itself can be the event causing irreversibility in DCD. Legislative abandonment of the dead donor rule to permit the recovery of transplantable organs is necessary in the absence of an adequate scientific foundation for DCD practice. The designation of organ procurement organizations or affiliates to obtain organ donation consent introduces self-serving bias and conflicts of interest that interfere with true informed consent. It is important that donors and their families are not denied a 'good death', and the impact of DCD on quality of end-of-life care has not been satisfactorily addressed to achieve this.
机译:循环死亡后的捐赠可以在神经系统完好的捐献者身上进行,这些捐献者在循环停止之前不符合神经或脑死亡标准。这篇评论着重讨论了在美国各地医院因强制性实施DCD导致即将发生的或心脏性死亡而引起的最有争议的捐助者相关问题。我们对选定的出版物和网站进行了非结构化审查,以进行数据提取和综合。当将其应用于神经功能完好的捐献者时,建议的5分钟循环停搏不能普遍满足死捐献者规则。循环停搏中体外灌注的科学证据表明,采购过程本身可能是导致DCD不可逆转的事件。在缺乏DCD实践的科学依据的情况下,有必要立法废除死者捐献者规则以允许恢复可移植器官。指定器官采购组织或附属机构以获得器官捐赠同意会引入自我服务的偏见和利益冲突,从而干扰真正的知情同意。重要的是,不要拒绝捐助者及其家人“好死”,而DCD对临终护理质量的影响尚未得到令人满意的解决。

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