Water Extract of Gastrodia Elate Blume May Ameliorate Subchronic and Mild Social Defeat Stress-induced Behavior Through Gut-brain Axis in Mice (P14-018-19)

摘要

ObjectivesGut has been known as the second brain and affects the brain via various pathways such as neurotransmitter modulation. We previously showed that water extract of Gastrodia elate Blume (WGE) exerts antidepression-like effect in forced swimming test. However, the impact of WGE on gut in subchronic and mild social defeat stress (sCSDS) model has not studied. Thus, we investigate the potential gut-brain linked mechanisms of WGE in relieving stress-induced depression-like behaviors which may result from the tryptophan (TRP) metabolism in mice subjected to sCSDS model.