Cadmium at Human Dietary Levels Disturbed Homeostasis of Nutritional Metals in Lung (P24-055-19)

摘要

ObjectivesMultiple metals are present in the human diet, with some being required as essential inorganic nutrients and all causing toxicity in excess or deficiency. Cadmium (Cd), a toxic heavy metal accumulates in human organs, kidney, liver and lung via food consumption. Our recent mouse studies showed that Cd decreased lung selenium level, and caused metabolic and transcriptomic disruption. However, little is known about the effects of Cd on nutritional metal distribution and subsequent impact on human health. In this study, we examined effects of oral Cd on distribution and interaction of nutritional metals in mouse lung.