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Relationship between nm23H1 genetic instability and clinical pathological characteristics in Chinese digestive system cancer patients

机译:中国消化系统癌症患者nm23H1基因不稳定性与临床病理特征的关系

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摘要

AIM: To study the relationship between nm23H1 gene genetic instability and its clinical pathological characteristics in Chinese digestive system cancer patients.METHODS: Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) was used to analyze the microsatellite instability (MSI) and loss of heterozygosity (LOH). Immunohistochemistry was employed to detect the expression of nm23H1.RESULTS: The MSI was higher in TNM stageI + II than in stage III + IV of gastric, colonic and gallbladder carcinomas. The LOH was higher in TNM stage III + IV than in stageI + II of gastric, colonic and hepatocellular carcinomas. Lymphatic metastasis was also observed. The expression of nm23H1 protein was lower in TNM stage III + IV than in stageI + II of these tumors and in patients with lymphatic metastasis.The nm23H1 protein expression was higher in the LOH negative group than in the LOH positive group.CONCLUSION: MSI and LOH may independently control the biological behaviors of digestive system cancers. MSI could serve as an early biological marker of digestive system cancers. Enhanced expression of nm23H1 protein could efficiently inhibit cancer metastasis and improve its prognosis. LOH mostly appears in late digestive system cancer.
机译:目的:探讨中国消化系统癌症患者nm23H1基因遗传不稳定性与其临床病理特征的关系。方法:采用聚合酶链反应-单链构象多态性(PCR-SSCP)分析微卫星不稳定性(MSI)和丢失杂合性(LOH)。结果:TNM I + II期的MSI高于胃癌,结肠癌和胆囊癌的III + IV期。胃癌,结肠癌和肝细胞癌的TNM III + IV期LOH高于I + II期。还观察到淋巴转移。在TNM III + IV期和淋巴结转移患者中,nm23H1蛋白的表达低于I + II期和淋巴结转移患者.LOH阴性组的nm23H1蛋白表达高于LOH阳性组。 LOH可独立控制消化系统癌症的生物学行为。 MSI可以作为消化系统癌症的早期生物学标记。 nm23H1蛋白的表达增强可以有效抑制癌症转移并改善其预后。 LOH主要出现在晚期消化系统癌症中。

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