Comparative analysis of hepatitis C virus phylogenies from coding and non-coding regions: the 5 untranslated region (UTR) fails to classify subtypes

摘要

BackgroundThe duration of treatment for HCV infection is partly indicated by the genotype of the virus. For studies of disease transmission, vaccine design, and surveillance for novel variants, subtype-level classification is also needed. This study used the Shimodaira-Hasegawa test and related statistical techniques to compare phylogenetic trees obtained from coding and non-coding regions of a whole-genome alignment for the reliability of subtyping in different regions.