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Obsessive-compulsive disorder: Evidence-based treatments and future directions for research

机译:强迫症:循证治疗和研究的未来方向

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摘要

Over the past three decades, obsessive-compulsive disorder (OCD) has moved from an almost untreatable, life-long psychiatric disorder to a highly manageable one. This is a very welcome change to the 1%-3% of children and adults with this disorder as, thanks to advances in both pharmacological and psychological therapies, prognosis for those afflicted with OCD is quite good in the long term, even though most have comorbid disorders that are also problematic. We still have far to go, however, until OCD can be described as either easily treatable or the effective treatments are widely known about among clinicians. This review focuses on the current state of the art in treatment for OCD and where we still are coming up short in our work as a scientific community. For example, while the impact of medications is quite strong for adults in reducing OCD symptoms, current drugs are only somewhat effective for children. In addition, there are unacceptably high relapse rates across both populations when treated with pharmacological alone. Even in the cognitive-behavioral treatments, which show higher effect sizes and lower relapse rates than drug therapies, drop-out rates are at a quarter of those who begin treatment. This means a sizable portion of the OCD population who do obtain effective treatments (which appears to be only a portion of the overall population) are not effectively treated. Suggestions for future avenues of research are also presented. These are primarily focused on (1) increased dissemination of effective therapies; (2) augmentation of treatments for those with residual symptoms, both for psychotherapy and pharmacotherapy; and (3) the impact of comorbid disorders on treatment outcome.
机译:在过去的三十年中,强迫症(OCD)已从几乎无法治愈的,终生的精神疾病转变为高度易于控制的疾病。对于患有这种疾病的1%-3%的儿童和成人来说,这是一个非常可喜的变化,因为得益于药物和心理疗法的发展,即使大多数人患有强迫症,长期来看,他们的预后也相当好也有问题的合并症。但是,在强迫症被描述为易于治疗或临床医生之间广为人知之前,我们还有很长的路要走。这篇综述着重介绍了强迫症治疗的最新技术,以及我们作为科学界仍在做的工作。例如,虽然药物对成年人减轻OCD症状的影响很大,但目前的药物仅对儿童有效。此外,当单独用药理学治疗时,两个人群的复发率都高得令人无法接受。即使在认知行为治疗中,与药物治疗相比,其效果更大,复发率更低,但辍学率仅为开始治疗者的四分之一。这意味着确实获得有效治疗的大部分强迫症患者(看来只是总人口的一部分)没有得到有效治疗。还提出了有关未来研究途径的建议。这些主要集中在(1)增加有效疗法的传播; (2)增加对残留症状者的心理治疗和药物治疗; (3)合并症对治疗结果的影响。

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