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Increase of cyclooxygenase-2 inhibition with celecoxib combined with 5-FU enhances tumor cell apoptosis and antitumor efficacy in a subcutaneous implantation tumor model of human colon cancer

机译：在人类结肠癌皮下植入肿瘤模型中塞来昔布联合5-FU增强对环氧合酶-2的抑制作用可增强肿瘤细胞凋亡和抗肿瘤功效

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摘要

BackgroundThe purpose of this study was to investigate the anti-tumor effect and explore the mechanisms of celecoxib (a selective cyclooxygenase-2 inhibitor) combined with 5-fluorouracil (5-FU) on the treatment of human colorectal cancer in a BALB/C nude mouse subcutaneous xenograft model.

机译：背景本研究的目的是研究塞来昔布（选择性环加氧酶2抑制剂）与5-氟尿嘧啶（5-FU）联合使用对BALB / C裸鼠人大肠癌的抗肿瘤作用并探讨其机制。小鼠皮下异种移植模型。

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期刊名称 World Journal of Surgical Oncology
作者
De-Qing Zhang; Qiang Guo; Jian-Hong Zhu; Wei-Chang Chen;
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作者单位

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年(卷),期 2013(11),-1
年度 2013
页码 16
总页数 8
原文格式 PDF
正文语种
中图分类外科学;肿瘤学;
关键词
Celecoxib 5-Fluorouracil Colorectal cancer Apoptosis;

机译：塞来昔布;5-氟尿嘧啶;结肠直肠癌;细胞凋亡;

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专利

1. 积雪草甙诱导肿瘤细胞凋亡及增强长春新碱的抗肿瘤作用 [J] . 黄云虹, 张胜华, 甄瑞贤, 癌症（英文版） . 2004,第012期
2. Increase of cyclooxygenase-2 inhibition with celecoxib combined with 5-FU enhances tumor cell apoptosis and antitumor efficacy in a subcutaneous implantation tumor model of human colon cancer [J] . De-Qing Zhang, Qiang Guo, Jian-Hong Zhu, World Journal of Surgical Oncology . 2013,第1期

机译：在人类结肠癌皮下植入肿瘤模型中，塞来昔布联合5-FU增强环氧合酶-2抑制作用可增强肿瘤细胞凋亡和抗肿瘤功效
3. Increase of cyclooxygenase-2 inhibition with celecoxib combined with 5-FU enhances tumor cell apoptosis and antitumor efficacy in a subcutaneous implantation tumor model of human colon cancer [J] . De-Qing Zhang, Qiang Guo, Jian-Hong Zhu, World Journal of Surgical Oncology . 2013,第1期

机译：在人类结肠癌皮下植入肿瘤模型中，塞来昔布联合5-FU增强环氧合酶-2抑制作用可增强肿瘤细胞凋亡和抗肿瘤功效
4. 99 Combined inhibition of {EGFR} and protein kinase {CK2} synergistically blocks phosphorylation of ribosomal protein S6, induces apoptosis in cancer cells and displays enhanced antitumor activity in xenograft models [J] . D. Drygin, J. Bliesath, A. Siddiqui-Jain, European Journal of Cancer Supplements . 2010,第7期

机译：99对 {EGFR }和蛋白激酶 {CK2 }的联合抑制可协同阻断核糖体蛋白S6的磷酸化，诱导癌细胞凋亡并在异种移植模型中显示增强的抗肿瘤活性
5. Combined Administration of 5-FU with CDHP Exert Synergistic Antitumor Effect for 5-FU Resistant Gastric Cancer Cells [C] . E, Sasaki, K. Tominaga, International Gastric Cancer Congress . 2005

机译：5-FU的组合施用CDHP施加5-FU耐胃癌细胞的协同抗肿瘤效果
6. Inhibition of Epithelial-to-Mesenchymal Transition by Antitumor Agents in Cancer Cells [D] . Chou, Chih-Chien 2014

机译：抗肿瘤剂在癌细胞中抑制上皮向间充质转化
7. Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models [O] . Hui Qin Wang, Ensar Halilovic, Xiaoyan Li, 2017

机译：联合的ALK和MDM2抑制作用可增加抗肿瘤活性并克服人ALK突变型神经母细胞瘤细胞系和异种移植模型中的耐药性
8. Increase of cyclooxygenase-2 inhibition with celecoxib combined with 5-FU enhances tumor cell apoptosis and antitumor efficacy in a subcutaneous implantation tumor model of human colon cancer [O] . De-Qing Zhang, Qiang Guo, Jian-Hong Zhu, 2013

机译：在人类结肠癌皮下植入肿瘤模型中，塞来昔布联合5-FU增强对环氧合酶-2的抑制作用可增强肿瘤细胞凋亡和抗肿瘤功效

Increase of cyclooxygenase-2 inhibition with celecoxib combined with 5-FU enhances tumor cell apoptosis and antitumor efficacy in a subcutaneous implantation tumor model of human colon cancer

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