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Recombinant horse interleukin-4 and interleukin-10 induced a mixed inflammatory cytokine response in horse peripheral blood mononuclear cells

机译：重组马白细胞介素4和白细胞介素10诱导马外周血单个核细胞中混合的炎性细胞因子反应

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摘要

Background and Aim:Interleukin (IL)-4 and IL-10 activate plethora of immune cells and induce the humoral immune response. However, recombinant version of horse IL-4 and IL-10 has not been investigated to understand their immunomodulating activities. This study aimed to produce recombinant horse mature IL-4 and IL-10 in Escherichia coli. Immune-modulating activities of recombinant horse IL-4 and IL-10 were investigated in peripheral blood mononuclear cells (PBMCs).

机译：背景与目的：白介素（IL）-4和IL-10激活过多的免疫细胞并诱导体液免疫反应。但是，尚未研究马IL-4和IL-10的重组形式以了解其免疫调节活性。这项研究旨在在大肠杆菌中生产重组的马成熟IL-4和IL-10。研究了重组马IL-4和IL-10在外周血单个核细胞（PBMC）中的免疫调节活性。

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期刊名称 Veterinary World
作者
Sheetal Saini; Harisankar Singha; Priyanka Siwach; B. N. Tripathi;
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作者单位

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年(卷),期 2019(12),4
年度 2019
页码 496–503
总页数 8
原文格式 PDF
正文语种
中图分类动物医学（兽医学）;
关键词
cell proliferation cytokines enzyme-linked immunosorbent assay real-time polymerase chain reaction;

机译：细胞增殖;细胞因子;酶联免疫吸附测定;实时聚合酶链反应;

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专利

1. Recombinant horse interleukin-4 and interleukin-10 induced a mixed inflammatory cytokine response in horse peripheral blood mononuclear cells [J] . Sheetal Saini, Harisankar Singha, Priyanka Siwach, Veterinary World . 2019,第4期

机译：重组马白细胞介素4和白细胞介素10诱导马外周血单个核细胞中混合的炎性细胞因子反应
2. APL-2, an altered peptide ligand derived from heat-shock protein 60, induces interleukin-10 in peripheral blood mononuclear cell derived from juvenile idiopathic arthritis patients and downregulates the inflammatory response in collagen-induced arthritis model [J] . Lorenzo Norailys, Cantera Dolores, Barbera Ariana, Clinical and experimental medicine . 2015,第1期

机译：APL-2是一种由热休克蛋白60衍生的改变的肽配体，可在幼年特发性关节炎患者的外周血单个核细胞中诱导白介素10，并下调胶原诱导的关节炎模型中的炎症反应
3. Infection of peripheral blood mononuclear cells with neuropathogenic equine herpesvirus type-1 strain Ab4 reveals intact interferon-alpha induction and induces suppression of anti-inflammatory interleukin-10 responses in comparison to other viral strains [J] . Wagner Bettina, Wimer Christine, Freer Heather, Veterinary Immunology and Immunopathology . 2011,第1a2期

机译：与其他病毒株相比，用神经致病性马疱疹病毒1型菌株Ab4感染外周血单核细胞可显示完整的干扰素α诱导并抑制抗炎性白介素10反应。
4. IN VITRO CYTOKINE EXPRESSION INDUCED BY INMODULEN~(R) IN PORCINE MACROPHAGES AND PERIPHERAL BLOOD MONONUCLEAR CELLS [C] . G. Pappaterra, E. Mateu, M. Martin, Congress of the International Pig Veterinary Society . 2000

机译：在猪巨噬细胞和外周血单核细胞中inmodulen〜（R）诱导的体外细胞因子表达
5. Proopiomelanocortin production by human peripheral blood mononuclear cells: Induction by inflammatory cytokines and potential paracrine loop. [D] . Gregg, Michael Thomas. 1996

机译：人外周血单核细胞产生丙型黑皮质素：由炎性细胞因子和潜在的旁分泌环诱导。
6. Recombinant fimbriae protein of Porphyromonas gingivalis induces an inflammatory response via the TLR4/NF-κB signaling pathway in human peripheral blood mononuclear cells [O] . Jing Cai, Jiangman Chen, Huanxu Guo, -1

机译：牙龈卟啉单胞菌的重组菌毛蛋白通过TLR4 /NF-κB信号通路诱导人外周血单个核细胞中的炎症反应
7. Recombinant horse interleukin-4 and interleukin-10 induced a mixed inflammatory cytokine response in horse peripheral blood mononuclear cells [O] . Sheetal Saini, Harisankar Singha, Priyanka Siwach, 2019

机译：重组马白细胞介素-4和白细胞介素-10在马外周血单核细胞中诱导混合炎性细胞因子反应

Recombinant horse interleukin-4 and interleukin-10 induced a mixed inflammatory cytokine response in horse peripheral blood mononuclear cells

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