Food Allergy: 73 IFN-ã Induces Milk Allergen-Specific IL-10-Producing Regulatory B Cells in Non-IGE Mediated Milk Allergy

摘要

BackgroundTolerance induction is one of the most important concerns in the treatment of allergies and autoimmune diseases. L-10-producing regulatory B cells (Br1s) seem to have a role in immune tolerance to food allergens. Oral immunotherapy using IFN-gamma has been successful for food allergy treatmen. We were to investigate the effects of IFN-gamma on allergen-specific Br1 responses in milk allergy patients and milk-tolerant subjects to evaluate the mmunomodulatory effects of IFN-gamma on Br1 cell responses.