Designing Clinical Trials for Assessing the Effectiveness ofInterventions for Tinnitus

摘要

In the face of finite resources, allocations of research and health-care funding are dependent upon high-quality evidence. Historically, tinnitus has been the poor cousin of hearing science, with low-quality clinical research providing unreliable estimates of effect and with devices marketed for tinnitus without strong evidence for those product claims. However, the tinnitus field is changing. Key opinion leaders have recently made calls to the field to improve the design, implementation, and reporting of clinical trials, and there is growing intersectoral collaboration. The Tonndorf Lecture presented at the 1st World Tinnitus Congress and the 12th International Tinnitus Seminar in Warsaw, Poland, provided an opportunity to reflect on the present and future progress of tinnitus research and treatment and what is needed for the field to achieve success. The content of that lecture is summarized in this article. The main debate concerns the selection and reporting of outcomes in clinical trials of tinnitus. Comprehensive reviews of the literature confirm the diversity of the personal impact of tinnitus and illustrate a lack of consensus in what aspects oftinnitus should be assessed and reported in a clinical trial. Aninnovative project is described which engages the global tinnituscommunity (patients and professionals alike) in working together. Thisproject seeks to improve future tinnitus research by creating anevidence-based consensus about minimum reporting standards foroutcomes in clinical trials of a tinnitus intervention. The outputwill be a core set of important and critical outcomes to be measuredand reported in all clinical trials.