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Venous Thromboembolism Following Colorectal Surgery for Suspected or Confirmed Malignancy

机译:大肠手术后可疑或确诊恶性肿瘤的静脉血栓栓塞

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摘要

Surgery for colorectal cancer conveys a high risk of venous thromboembolism (VTE). The effect of thromboprophylactic regimens of varying duration on the incidence of VTE was assessed in 417 patients undergoing surgery between 2005 and 2009 for colorectal cancer. Low-dose unfractionated heparin (LDUH) was used in 52.7% of patients, low-molecular-weight heparin (LMWH) in 35.3%, and 10.7% received LDUH followed by LMWH. Pharmacological prophylaxis was continued after hospitalisation in 31.6%. Major bleeding occurred in 4% of patients. The 30-day mortality rate was 1.9%. The incidence of symptomatic VTE from hospital admission for surgery to 12 months after was 2.4%. There were no in-hospital VTE events. The majority of events occurred in the three-month period after discharge, but there were VTE events up to 12 months, especially in patients with more advanced cancer and multiple comorbidities.
机译:结直肠癌的手术具有很高的静脉血栓栓塞(VTE)风险。在2005年至2009年之间,对417名接受手术的大肠癌患者评估了不同持续时间的血栓预防方案对VTE发生率的影响。 52.7%的患者使用低剂量普通肝素(LDUH),35.3%的患者使用低分子量肝素(LMWH),10.7%的患者接受LDUH,其次是LMWH。住院后仍继续进行药理预防,占31.6%。 4%的患者发生大出血。 30天死亡率为1.9%。从手术入院到术后12个月的症状性VTE发生率为2.4%。没有医院内VTE事件。大多数事件发生在出院后的三个月内,但有VTE事件长达12个月,尤其是在患有晚期癌症和多种合并症的患者中。

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