首页> 美国卫生研究院文献>Stem Cell Research Therapy >Activation of Notch1 signalling promotes multi-lineage differentiation of c-KitPOS/NKX2.5POS bone marrow stem cells: implication in stem cell translational medicine

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Activation of Notch1 signalling promotes multi-lineage differentiation of c-KitPOS/NKX2.5POS bone marrow stem cells: implication in stem cell translational medicine

机译：Notch1信号的激活促进c-KitPOS / NKX2.5POS骨髓干细胞的多系分化：在干细胞转化医学中的意义

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IntroductionTransplantation of bone marrow mesenchymal stem cells (BMSCs) can repair injured hearts. However, whether BMSC populations contain cells with cardiac stem cell characteristics is ill-defined. We report here that Notch signalling can promote differentiation of c-Kit^POS/NKX2.5^POS BMSCs into cardiomyocyte-like cells.

机译：简介骨髓间充质干细胞（BMSCs）的移植可以修复受伤的心脏。但是，BMSC群体是否包含具有心脏干细胞特征的细胞尚不清楚。我们在这里报告Notch信号可以促进c-Kit ^{POS /NKX2.5 ^{POS BMSCs向心肌样细胞的分化。}}

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期刊名称 Stem Cell Research Therapy
作者
Ranran Ding; Xiaofan Jiang; Yanping Ha; Zhenliang Wang; Junli Guo; Hanguo Jiang; Shaojiang Zheng; Zhihua Shen; Wei Jie;
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作者单位

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年(卷),期 2015(6),1
年度 2015
页码 91
总页数 15
原文格式 PDF
正文语种
中图分类细胞生物学;医学史;
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专利

1. Activation of Notch1 signalling promotes multi-lineage differentiation of c-KitPOS/NKX2.5POS bone marrow stem cells: implication in stem cell translational medicine [J] . Ranran Ding, Xiaofan Jiang, Yanping Ha, Stem Cell Research & Therapy . 2015,第1期

机译：Notch1信号的激活促进c-KitPOS / NKX2.5POS骨髓干细胞的多系分化：在干细胞转化医学中的意义
2. Bone marrow mesenchymal stem cells promote prostate cancer cell stemness via cell–cell contact to activate the Jagged1/Notch1 pathway [J] . Ji-wen Cheng, Li-xia Duan, Yang Yu, Cell & Bioscience . 2021,第1期

机译：骨髓间充质干细胞通过细胞 - 细胞接触促进前列腺癌细胞茎以激活锯齿状1 / Notch1途径
3. Extracellular signal-regulated kinase1/2 activated by fluid shear stress promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells through novel signaling pathways. [J] . Liu L, Shao L, Li B, The international journal of biochemistry and cell biology . 2011,第11期

机译：流体剪切应力激活的细胞外信号调节激酶1/2通过新的信号通路促进人骨髓间充质干细胞的成骨分化。
4. Low level light promotes the proliferation and differentiation of bone marrow derived mesenchymal stem cells [C] . Jin-Chul Ahn, Yun-Hee Rhee, Sun-Hyang Choi, Mechanisms for low-light therapy X . 2015

机译：低强度光促进骨髓源性间充质干细胞的增殖和分化
5. Adhesion to bone marrow extracellular matrix proteins promotes the osteogenic differentiation of human mesenchymal stem cells [D] . Salasznyk, Roman Mike 2005

机译：对骨髓细胞外基质蛋白的粘附促进人间充质干细胞的成骨分化
6. Bone marrow mesenchymal stem cells promote prostate cancer cell stemness via cell–cell contact to activate the Jagged1/Notch1 pathway [O] . Ji-wen Cheng, Li-xia Duan, Yang Yu, 2021

机译：骨髓间充质干细胞通过细胞 - 细胞接触促进前列腺癌细胞茎以激活锯齿状1 / Notch1途径
7. Activation of Notch1 signalling promotes multi-lineage differentiation of c-Kit/NKX2.5 bone marrow stem cells: implication in stem cell translational medicine [O] . 2015

机译：Notch1信号的激活促进c-Kit / NKX2.5骨髓干细胞的多系分化：在干细胞转化医学中的意义

Activation of Notch1 signalling promotes multi-lineage differentiation of c-KitPOS/NKX2.5POS bone marrow stem cells: implication in stem cell translational medicine

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