Objectives. The purpose of this study was to identify the predictors of acquired perforating dermatosis (APD) in patients on maintenance hemodialysis (HD). Methods. A case-control study was performed at our outpatient HD center between January 1, 2000 and March 31, 2011. Patients on HD with APD were matched (1 : 2) for gender and age with controls on HD. Conditional logistic regression was used to identify factors associated with APD. Results. A total of 19 patients with APD and 38 age and gender matched patients were enrolled in the study. Univariate logistic regression showed that APD was significantly associated with diabetes mellitus (DM), reduced levels of intact parathyroid hormone (iPTH) and albumin (Alb), reduced dialysis adequacy (Kt/V) and urea reduction rate (URR), and elevated levels of high-sensitivity C-reactive protein (hsCRP). Multivariate logistic regression identified reduced iPTH (hazard ratio (HR): 0.983; P = 0.026) and Alb (HR: 0.099; P = 0.047) and elevated hsCRP (HR: 1.210, P = 0.024) as risk factors for APD. Conclusions. iPTH, hsCRP, and Alb are predictors for APD in HD patients.
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机译：目标。这项研究的目的是确定维持性血液透析（HD）患者中获得性穿孔性皮肤病（APD）的预测因子。方法。我们于2000年1月1日至2011年3月31日在我们的门诊HD中心进行了一项病例对照研究。HD和APD的患者在性别和年龄上均与HD对照相匹配（1：2）。条件对数回归用于确定与APD相关的因素。结果。共有19位APD患者和38位年龄和性别匹配的患者参加了研究。单因素逻辑回归分析表明，APD与糖尿病（DM），完整的甲状旁腺激素（iPTH）和白蛋白（Alb）降低，透析充分性（Kt / V）和尿素减少率（URR）降低以及水平升高显着相关高敏C反应蛋白（hsCRP）的鉴定。多元逻辑回归分析确定iPTH降低（危险比（HR）：0.983； P = 0.026）和Alb（HR：0.099； P = 0.047）和hsCRP升高（HR：1.210，P = 0.024）是APD的危险因素。结论。 iPTH，hsCRP和Alb是HD患者APD的预测因子。
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