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Original article: Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures

机译：原始文章：甲氨蝶呤对活动性类风湿关节炎患者血清细胞因子和淋巴细胞亚群的影响的长期研究：与药代动力学措施的相关性

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ObjectiveTo describe changes in immune parameters observed during long-term methotrexate (MTX) therapy in patients with active rheumatoid arthritis (RA) and explore correlations with simultaneously measured MTX pharmacokinetic (PKC) parameters.

机译：目的描述长期甲氨蝶呤（MTX）治疗活动性类风湿关节炎（RA）患者所观察到的免疫参数的变化，并探讨与同时测定的MTX药代动力学（PKC）参数之间的相关性。

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期刊名称 RMD Open
作者
Joel M Kremer; David A Lawrence; Robert Hamilton; Iain B McInnes;
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作者单位

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年(卷),期 2016(2),1
年度 2016
页码 e000287
总页数 11
原文格式 PDF
正文语种
中图分类
关键词
Cytokines Disease Activity Methotrexate Pharmacokinetics Rheumatoid Arthritis;

机译：细胞因子;疾病活性;甲氨蝶呤;药代动力学;类风湿关节炎;

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中文文献

1. Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures [J] . David A Lawrence, Joel M Kremer, Iain B McInnes, RMD Open . 2016,第1期

机译：甲氨蝶呤对活动性类风湿关节炎患者血清细胞因子和淋巴细胞亚群的影响的长期研究：与药代动力学措施的相关性
2. Association of serum markers with improvement in clinical response measures after treatment with golimumab in patients with active rheumatoid arthritis despite receiving methotrexate: results from the GO-FORWARD study. [J] . Visvanathan S, Rahman MU, Keystone E, Arthritis research & therapy. . 2010,第6期

机译：尽管接受甲氨蝶呤治疗的活动性类风湿关节炎患者在接受戈利木单抗治疗后血清标志物与临床反应措施改善之间的关联：GO-FORWARD研究的结果。
3. Association of serum markers with improvement in clinical response measures after treatment with golimumab in patients with active rheumatoid arthritis despite receiving methotrexate: results from the GO-FORWARD study [J] . Sudha Visvanathan, Mahboob U Rahman, Edward Keystone, Arthritis research & therapy. . 2010,第6期

机译：尽管接受甲氨蝶呤治疗的活动性类风湿性关节炎患者接受戈利木单抗治疗后血清标志物与临床反应措施改善之间的关联：GO-FORWARD研究的结果
4. Original article: Abatacept in combination with methotrexate in Japanese biologic-naive patients with active rheumatoid arthritis: a randomised placebo-controlled phase IV study [O] . Tsukasa Matsubara, Hiroshi Inoue, Toshihiro Nakajima, 2018

机译：原始文章：Abatacept联合甲氨蝶呤治疗日本初生性活动性类风湿关节炎患者：一项随机安慰剂对照的IV期研究
5. Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures [O] . Kremer Joel M., Lawrence David A., Hamilton Robert, 2016

机译：长期研究甲氨蝶呤对活动性类风湿性关节炎患者血清细胞因子和淋巴细胞亚群的影响：与药代动力学测量的相关性

Original article: Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures

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