Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration

摘要

BackgroundNicotinic acetylcholine receptors (nAChR) have been identified on a variety of cells of the immune system and are generally considered to trigger anti-inflammatory events. In the present study, we determine the nAChR inventory of rat alveolar macrophages (AM), and investigate the cellular events evoked by stimulation with nicotine.