Frontal Dysfunction Underlies Depression in Mild Cognitive Impairment: A FDG-PET Study

摘要

ObjectiveDepression is a very common symptom in people with mild cognitive impairment (MCI), a preclinical stage of Alzheimer's disease (AD), and in those with clinically evident AD. Moreover, MCI individuals with depression show a higher conversion rate to clinical AD than those without depression. This study aimed to elucidate the functional neuroanatomical substrate of depression in MCI.