Peptide charge state determination of tandem mass spectra from low-resolution collision induced dissociation

摘要

AbstractBackgroundCharge states of tandem mass spectra from low-resolution collision induced dissociation can not be determined by mass spectrometry. As a result, such spectra with multiple charges are usually searched multiple times by assuming each possible charge state. Not only does this strategy increase the overall database search time, but also yields more false positives. Hence, it is advantageous to determine charge states of such spectra before database search.