Transchromosomic cell model of Down syndrome shows aberrant migration adhesion and proteome response to extracellular matrix

摘要

BackgroundDown syndrome (DS), caused by trisomy of human chromosome 21 (HSA21), is the most common genetic birth defect. Congenital heart defects (CHD) are seen in 40% of DS children, and >50% of all atrioventricular canal defects in infancy are caused by trisomy 21, but the causative genes remain unknown.