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Addition of colchicine-tubulin complex to microtubule ends: The mechanism of substoichiometric colchicine poisoning

机译：在微管末端添加秋水仙碱-微管蛋白复合物：亚化学计量的秋水仙碱中毒的机制

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摘要

Colchicine blocks microtubule polymerization by an unusual substoichiometric poisoning mechanism. We have investigated the mechanism by which this poisoning occurs with several experimental approaches, and have found that colchicine acts by addition to microtubule ends as a colchicine-tubulin complex.

机译：秋水仙碱通过一种异常的亚化学计量的中毒机制阻止微管聚合。我们用几种实验方法研究了这种中毒发生的机理，并发现秋水仙碱通过向微管末端添加而作为秋水仙碱-微管蛋白复合物起作用。

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期刊名称 Proceedings of the National Academy of Sciences of the United States of America
作者
Robert L. Margolis; Leslie Wilson;
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年(卷),期 1977(74),8
年度 1977
页码 3466–3470
总页数 5
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1. KINETIC STABILIZATION OF MICROTUBULE DYNAMICS AT STEADY STATE IN VITRO BY SUBSTOICHIOMETRIC CONCENTRATIONS OF TUBULIN-COLCHICINE COMPLEX [J] . Panda D, Daijo JE, Jordan MA, Biochemistry . 1995 ,第31期

机译：分子微管浓度的微管蛋白-高铁化学络合物在体外稳态下微管动力学的动力学稳定
2. Response of microtubules to the addition of colchicine and tubulin-colchicine: Evaluation of models for the interaction of drugs with microtubules [J] . Vandecandelaere A, Martin SR, Engelborghs Y The Biochemical Journal . 1997 ,第Pta1期

机译：微管对秋水仙碱和微管蛋白-秋水仙碱添加的反应：药物与微管相互作用模型的评估
3. Response of microtubules to the addition of colchicine and tubulin–colchicine: evaluation of models for the interaction of drugs with microtubules [J] . André VANDECANDELAERE, Stephen R. MARTIN, Yves ENGELBORGHS The biochemical journal . 1997 ,第1期

机译：补充秋水仙碱和微管蛋白-秋水仙碱对微管的反应：药物与微管相互作用模型的评估
4. Phenylahistin,a small dipeptidic colchicine-like anti-microtubule agent:total synthesis and SAR study of the derivatives [C] . Yoshio Hayashi, Sumie Orikasa, Koji Tanaka, the International Peptide Symposium . 2001

机译：苯吡啶，一种小二肽血清晶氨酸样抗微管剂：衍生物的总合成和SAR研究
5. Molecular Mechanisms of Kinetochore-Microtubule Attachment Via the Ndc80 Complex [D] . Alushin, Gregory Matthew 2012

机译：通过Ndc80复合物的线粒体-微管附着的分子机制。
6. Response of microtubules to the addition of colchicine and tubulin-colchicine: evaluation of models for the interaction of drugs with microtubules. [O] . A Vandecandelaere, S R Martin, Y Engelborghs 1997

机译：微管对秋水仙碱和微管蛋白-秋水仙碱添加的反应：药物与微管相互作用模型的评估。
7. Addition of colchicine-tubulin complex to microtubule ends: The mechanism of substoichiometric colchicine poisoning [O] . Margolis, Robert L., Wilson, Leslie 1977

机译：在微管末端添加秋水仙碱-微管蛋白复合物：亚化学计量的秋水仙碱中毒的机制
8. Semi-Synthesis and In-vitro Anticancer Evaluation of Derivatives of a New Microtubule Poison with a Taxol-Like Mechanism [R] . Hemscheidt, T. K. 2004

机译：具有紫杉醇类机制的新型微管毒物衍生物的半合成和体外抗癌评价

Addition of colchicine-tubulin complex to microtubule ends: The mechanism of substoichiometric colchicine poisoning

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