Renal impairment is common amongst elderly patients and increases the risk of drug toxicity. Analysis of the discharge summaries of patients discharged from the geratology wards of an Oxfordshire hospital, showed that renal impairment was not referred to in 42% of patients with calculated creatinine clearances of 10-20 ml/min. A fifth of these patients, and 67% of patients with calculated creatinine clearances < 10 ml/min, had discharge drug prescriptions that contradicted the British National Formulary guidelines for prescribing in the presence of renal impairment. There should be increased awareness that, in elderly patients, normal serum creatinine concentrations do not exclude renal impairment and that several commonly prescribed drugs require dose adjustments or should be avoided in the presence of renal insufficiency.
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机译：肾损伤在老年患者中很常见，并增加了药物毒性的风险。从牛津郡一家医院的老年病房出院的患者的出院总结分析表明，在42％的肌酐清除率为10-20 ml / min的患者中未提及肾功能不全。这些患者中的五分之一，以及67％的肌酐清除率<10 ml / min的患者，其出院药物处方与英国国家处方药指南中存在肾功能不全的处方相抵触。应当提高认识，在老年患者中，正常的血清肌酐浓度不能排除肾功能不全，几种常用处方药需要调整剂量，或者在存在肾功能不全的情况下应避免使用。
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