首页> 美国卫生研究院文献>Pain Reports >Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain

【2h】

Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain

机译：组织蛋白酶K抑制剂L-006235在骨关节炎疼痛碘乙酸单钠模型中的镇痛作用

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

Introduction:The mounting evidence that osteoclasts play an important role in osteoarthritis (OA) pain lead us to investigate the effects of L-006235, a potent and selective inhibitor of cathepsin K, on pain behaviour and joint pathology in a model of OA pain.

机译：简介：越来越多的证据表明破骨细胞在骨关节炎（OA）疼痛中起重要作用，这促使我们研究了组织蛋白酶K的有效选择性抑制剂L-006235在OA疼痛模型中对疼痛行为和关节病理的影响。

著录项

期刊名称 Pain Reports
作者
Lilian N. Nwosu; Peter R.W. Gowler; James J. Burston; Biljana Rizoska; Karin Tunblad; Erik Lindström; Urszula Grabowska; Li Li; Dan F. McWilliams; David A. Walsh; Victoria Chapman;
展开▼
作者单位

展开▼
年(卷),期 2018(3),6
年度 2018
页码 e685
总页数 12
原文格式 PDF
正文语种
中图分类基础医学;
关键词
Osteoclast Pain Joint Rat Osteoarthritis;

机译：破骨细胞;疼痛;关节;大鼠;骨关节炎;

相似文献

外文文献
中文文献
专利

1. Deficits in spontaneous burrowing behavior in the rat bilateral monosodium iodoacetate model of osteoarthritis: an objective measure of pain-related behavior and analgesic efficacy [J] . Bryden L. A., Nicholson J. R., Doods H., Osteoarthritis and cartilage . 2015,第9期

机译：骨关节炎大鼠双侧碘乙酸单钠模型中自发性穴位行为的不足：疼痛相关行为和止痛功效的客观衡量
2. Ameliorative effects of green tea seed extract with rose hip powder (Rosa canina L.) on regulation of pain and inflammatory cytokines in a rat model of monosodium iodoacetate-induced experimental osteoarthritis [J] . Jeong Changsik, Bae Donghyuck, Lim Heungyoul, Animal Cells and Systems . 2015,第1期

机译：玫瑰果粉（Rosa canina L.）绿茶种子提取物对碘乙酸单钠诱发的实验性骨关节炎大鼠模型中疼痛和炎性细胞因子的调节作用
3. Ameliorative effects of green tea seed extract with rose hip powder (Rosa canina L.) on regulation of pain and inflammatory cytokines in a rat model of monosodium iodoacetate-induced experimental osteoarthritis [J] . Changsik Jeong, Donghyuck Bae, Heungyoul Lim, Animal Cells and Systems . 2015,第1期

机译：玫瑰果粉（Rosa canina L.）绿茶种子提取物对碘乙酸单钠诱发的实验性骨关节炎大鼠模型中疼痛和炎性细胞因子的调节作用
4. An interpretable model for predicting side effects of analgesics for osteoarthritis [C] . Liangliang Liu, Jianxin Wang, Min Li, IEEE International Conference on Bioinformatics and Biomedicine . 2017

机译：一种可预测的模型，用于预测镇痛药对骨关节炎的副作用
5. In Vivo Fluorescence Reflectance Imaging to Quantify Sex-Based Differences in Protease, MMP, and Cathepsin K Activity in a Mouse Model of Post-Traumatic Osteoarthritis. [D] . Satkunananthan, Patrick Bavan. 2013

机译：体内荧光反射成像可量化创伤后骨关节炎小鼠模型中蛋白酶，MMP和组织蛋白酶K活性的基于性别的差异。
6. Dose Dependent Effects of Whole Blueberry on Cartilage Health and Pain in a Monosodium Iodoacetate (MIA) Induced Rat Model of Osteoarthritis [O] . Sanique South, Keith Crabtree, Parakat Vijayagopal, 2020

机译：整个蓝莓对碘乙酸单钠（MIA）诱导的骨关节炎大鼠软骨健康和疼痛的剂量依赖性影响
7. Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain [O] . Lilian N. Nwosu, Peter R.W. Gowler, James J. Burston, 2018

机译：组织蛋白酶K抑制剂L-006235在骨关节炎疼痛中碘碘酸钠模型中的镇痛作用

Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain

摘要

著录项

相似文献

相关主题

期刊订阅