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Age-specific impact on the survival of gastric cancer patients with distant metastasis: an analysis of SEER database

机译:年龄差异对胃癌远处转移患者生存的影响:SEER数据库分析

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摘要

The age-specific impact on the survival of gastric cancer patients with distant metastasis is still unclear. In this study, we identified 11, 299 gastric cancer patients with distant metastasis between 2004 and 2013 from Surveillance, Epidemiology, and End Results population-based dataset. Patients were divided into young (≤60) and elderly groups (>60). Kaplan-Meier methods and multivariable Cox regression were used for the analysis of long-term survival outcomes and risk factors. There were significant differences between the two groups in terms of race, primary site, grade, histologic type, surgery, marital status and clinical T stage (P<0.05). The 1- and 3-year cancer specific survival rates were 29.0% and 6.2% in young group and 22.8% and 4.8% in elderly group in both univariate (X2=116.430, P<0.001) and multivariate analysis (P<0.001). Young patients had significantly better 1- and 3-year cancer specific survival than elderly patients in each T stage. Age was further validated as an independent survival factor in all T stages (T1, T2, T3, T4 and TX, P<0.05). In conclusion, age was an independent prognostic factor for gastric cancer patients with distant metastasis.
机译:尚不清楚年龄远期转移对胃癌患者生存的影响。在这项研究中,我们从监测,流行病学和最终结果人群数据集中,确定了2004年至2013年之间11例299例远处转移的胃癌患者。将患者分为年轻组(≤60)和老年组(> 60)。使用Kaplan-Meier方法和多变量Cox回归分析长期生存结局和危险因素。两组在种族,原发部位,等级,组织学类型,手术,婚姻状况和临床T分期方面存在显着差异(P <0.05)。单变量(X 2 = 116.430,P <0.001)和年轻人的1年和3年癌症特异性生存率在年轻组中分别为29.0%和6.2%,在老年组中分别为22.8%和4.8%。多元分析(P <0.001)。在每个T期中,年轻患者的1年和3年癌症特异性生存率明显高于老年患者。年龄被进一步确认为所有T期(T1,T2,T3,T4和TX,P <0.05)的独立生存因素。总之,年龄是胃癌远处转移患者的独立预后因素。

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