SKF95365 induces apoptosis and cell-cycle arrest by disturbing oncogenic Ca2+ signaling in nasopharyngeal carcinoma cells

摘要

BackgroundAberrant modulation of store-operated calcium ions (Ca²⁺) entry promotes the progression of human malignancies. Previously, we reported that the blockage of store-operated Ca²⁺ entry inhibited epidermal growth factor (EGF)-stimulated migration and distant metastasis in nasopharyngeal carcinoma (NPC) cells. However, the effects of pharmacological blocker on other Ca²⁺ signaling-regulated malignant characteristics in NPC cells remained poorly understood.