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Tumor heterogeneity as a rationale for a multi-epitope approach in an autologous renal cell cancer tumor vaccine

机译：肿瘤异质性作为自体肾细胞癌肿瘤疫苗中多表位方法的基础

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PurposeAn autologous tumor vaccine already used successfully in the immune therapy of renal cell carcinoma was investigated in detail. The evaluation of potential tumor markers should allow for the assessment of potency according to pharmaceutical regulations.

机译：目的详细研究已经成功用于肾细胞癌免疫治疗的自体肿瘤疫苗。潜在的肿瘤标志物的评估应允许根据药物法规评估效力。

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期刊名称 OncoTargets and therapy
作者
Stefan Wittke; Susann Baxmann; Dirk Fahlenkamp; Stephan T Kiessig;
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作者单位

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年(卷),期 2016(9),-1
年度 2016
页码 523–537
总页数 15
原文格式 PDF
正文语种
中图分类应用微生物学;肿瘤学;
关键词
renal cell carcinoma kidney cancer tumor-associated antigens tumor marker ELISA Western Blot immunotherapy therapeutic vaccine potency testing topological proteomics;

机译：肾细胞癌;肾癌;肿瘤相关抗原;肿瘤标志物;ELISA;Western Blot;免疫疗法;治疗性疫苗;效能测试;拓扑蛋白质组学;

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专利

1. Tumor heterogeneity as a rationale for a multi-epitope approach in an autologous renal cell cancer tumor vaccine [J] . Stefan Wittke OncoTargets and therapy . 2016,第1期

机译：肿瘤异质性作为自体肾细胞癌肿瘤疫苗中多表位方法的基础
2. Irradiated cells from autologous tumor cell lines as patient-specific vaccine therapy in 125 patients with metastatic cancer: induction of delayed-type hypersensitivity to autologous tumor is associated with improved survival. [J] . Dillman RO, Beutel LD, Barth NM, Cancer biotherapy and radiopharmaceuticals . 2002,第1期

机译：来自自体肿瘤细胞系的辐射细胞作为125例转移癌患者的患者特异性疫苗治疗：诱导对自体肿瘤的迟发型超敏反应与改善的生存率相关。
3. Allogeneic partially HLA-matched dendritic cells pulsed with autologous tumor cell lysate as a vaccine in metastatic renal cell cancer: A clinical phase I/II study [J] . Fl?rckenA., KoppJ., VanLessenA., Human vaccines & immunotherapeutics. . 2013,第6期

机译：自体肿瘤细胞裂解物脉冲同种异体部分HLA匹配的树突状细胞作为疫苗治疗转移性肾细胞癌：I / II期临床研究
4. CD40-ACTIVATED B (CD40-B) CELLS LOADED WITH AUTOLOGOUS TUMOR RNA AS A NOVEL ANTIGEN-PRESENTING CELL VACCINE FOR CANINE LYMPHOMA [C] . Amy LaBlanc, Erika L Krick, Beth Overley, Annual conference of the Veterinary Cancer Society . 2008

机译：CD40-活化的B（CD40-B）用自体肿瘤RNA负载，作为犬淋巴瘤的新型抗原呈递细胞疫苗
5. The development of intratumoral heterogeneity in ovarian tumors: Role of cancer stem cells in disease progression. [D] . Lunsford, Elaine P. 2014

机译：卵巢肿瘤内肿瘤异质性的发展：癌症干细胞在疾病进展中的作用。
6. Allogeneic partially HLA-matched dendritic cells pulsed with autologous tumor cell lysate as a vaccine in metastatic renal cell cancer [O] . Anne Flörcken, Joachim Kopp, Antje van Lessen, 2013

机译：自体肿瘤细胞裂解物脉冲治疗的同种异体部分HLA匹配树突状细胞作为转移性肾细胞癌的疫苗
7. Rationales for a multi-epitope approach in an autologous renal cell cancer timor vaccine [O] . Wittke Stefan, Baxmann Susann, Fahlenkamp Dirk, 2016

机译：对于自体肾细胞癌timor疫苗中的多表位方法是合理的

Tumor heterogeneity as a rationale for a multi-epitope approach in an autologous renal cell cancer tumor vaccine

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