GERM-10. EARLY DETECTION OF CNS GERMINOMA IN PITUITARY STALK THICKENING USING NON-INVASIVE microRNA TESTING

摘要

INTRODUCTIONPatients presenting with diabetes insipidus (DI) and subtle pituitary-stalk thickening on MRI represent a management challenge. LCH and germinoma work-up (including serum/CSF AFP/HCG) is usually negative, given the poor sensitivity of these tests. Risks of neurosurgical biopsy in such cases often outweigh perceived benefits. Consequently, biopsy is often only performed for radiological progression. This suboptimal approach may cause diagnostic delay and inferior outcomes. Non-invasive diagnostic microRNA testing for malignant germ cell tumours (MGCTs) has shown substantial promise. Here, we highlight the potential for microRNAs to facilitate earlier diagnosis of CNS germinoma.