P04.28 Effect of fibroblast activation protein-expressing stromal cells from human glioblastomas on glioma and endothelial cells

摘要

BackgroundFibroblast activation protein (FAP) is a protease selectively expressed in a number of extracranial cancers especially in cancer associated fibroblasts (CAF). CAF play an important role in the pathogenesis of malignant tumors through extracellular matrix remodeling, secretion of growth factors and cytokines, and promotion of angiogenesis and intratumoral immunosuppression. Glioblastomas (GBMs) have a unique composition of the tumor microenvironment and whether CAF are present in these tumors remains controversial. We have recently shown that FAP is upregulated in a subgroup of GBMs and is expressed in both cancer and stromal cells. The role of FAP+ stromal cells in GBM is however unknown.